Effect of Taxifolin on Lung Injury Induced by Staphylococcus aureus in Albino Wistar-Type Rats: A Biochemical and Histopathological Evaluation
INTERNATIONAL JOURNAL OF PHARMACOLOGY, cilt.19, 2023 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 19
- Basım Tarihi: 2023
- Doi Numarası: 10.3923/ijp.2023.623.631
- Dergi Adı: INTERNATIONAL JOURNAL OF PHARMACOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), BIOSIS, CAB Abstracts, EMBASE, Veterinary Science Database
- Erzincan Binali Yıldırım Üniversitesi Adresli: Evet
Özet
Background and Objective: Staphylococcus aureus is considered the main cause of pneumonia. Pneumonia is the most common cause
of acute lung injury. Taxifolin is a flavonol with antioxidant, anti-inflammatory, antimicrobial, antiviral, antifungal, anti-hyperglycemic,
anti-hyperlipidemic, anti-psoriatic and pulmono-protective activities. The present study aimed to biochemically and histopathologically
investigate the protective effect of taxifolin against possible acute lung oxidative and inflammatory damage caused by Staphylococcus
aureus (S. aureus) infection in rats. Materials and Methods: The rats were divided into three groups 6 rats each, healthy control (HG),
S. aureus inoculated (SaG) and S. aureus inoculated+taxifolin treated (SaT). Animals were euthanized. Malondialdehyde (MDA) total
glutathione (tGSH), Nuclear Factor kappa (NF-κB), Tumor Necrosis Factor-alpha (TNF-") and Interleukin One Beta (IL-1$) levels were
measured in the excised lung tissues and also examined histopathologically. Results: Staphylococcus aureus inoculation significantly
increased MDA, NF-κB, TNF-" and IL-1$ levels and decreased tGSH levels in lung tissue. Treatment with taxifolin significantly suppressed
the increase in MDA, NF-κB, TNF-" and IL-1$ levels and the decrease in tGSH levels. Histopathologically, Staphylococcus aureus inoculation
led to severe mononuclear cell infiltration in interstitial areas, lymphoid hyperplasia in bronchial-associated lymphoid tissue and
desquamation in bronchial epithelium. Treatment with taxifolin attenuated these histopathological findings. Conclusion: Current
experimental results suggested that taxifolin may be beneficial in the treatment of oxidative and inflammatory lung injury associated with
S. aureus infection.