Anti-inflammatory effects of selective COX-2 inhibitors


SULEYMAN H. , DEMIRCAN B., KARAGOZ Y., OZTASAN N., Suleyman B.

POLISH JOURNAL OF PHARMACOLOGY, cilt.56, ss.775-780, 2004 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 56 Konu: 6
  • Basım Tarihi: 2004
  • Dergi Adı: POLISH JOURNAL OF PHARMACOLOGY
  • Sayfa Sayıları: ss.775-780

Özet

In this study, effects of rofecoxib, celecoxib, nimesulide on the acute phase of inflammation were studied in the carrageenan-induced paw edema model and their influence on the chronic phase of inflammation was evaluated in the cotton pellet granuloma tests. Additionally, effects of these drugs on capillary vascular permeability were examined in the hyaluronidase test and were compared with that of indomethacin (nonselective COX inhibitor).