The effect of Hippophae rhamnoides extract on ischemia reperfusion-induced brain injury in rats

Ozbek Bilgin A., ALTUNER D., ÇANKAYA M., ÇAKIR T., MAMMADOV R., Bilgin Y., ...Daha Fazla

Latin American Journal of Pharmacy, cilt.38, sa.12, ss.2455-2462, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 12
  • Basım Tarihi: 2019
  • Dergi Adı: Latin American Journal of Pharmacy
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2455-2462
  • Anahtar Kelimeler: Brain, Hippophae rhamnoides, Ischemia reperfusion injury, Rat
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Evet

Özet

© 2019, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.The aim of this study was to examine the effects of Hippophae rhamnoides extract (HRE), known to have antioxidant properties, on ischemia reperfusion-induced brain injury in rats. Eighteen albino Wistar male rats were divided into three equal groups: 15 min of brain ischemia-3 h of reperfusion (BIR) group, 50 mg/kg HRE + brain ischemia-reperfusion (HRE + BIR) group, and control group for sham operation (SHAM). Malondialdehyde (MDA) level, myeloperoxidase (MPO) activity and 8-OHdG levels significantly increased, whereas total glutathione (tGSH) level, glutathione reductase (GSHRd), glutathione s-transferase (GST) activities decreased in the brain tissues of BIR group compared to SHAM group. HR application reversed these changes and brought the levels closer to the level of SHAM group. This study has revealed that HR inhibits IR-induced oxidative damage and inflammation in rat’s brain biochemically and it is effective in maintaining antioxidant activity and protecting against DNA damage in the tissue.