Vitamins Can Increase Antibiotic Effects Against Multidrug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii in an In Vitro Infection Model
Eurasian Journal of Medicine, cilt.56, sa.2, ss.91-97, 2024 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 56 Sayı: 2
- Basım Tarihi: 2024
- Doi Numarası: 10.5152/eurasianjmed.2024.23145
- Dergi Adı: Eurasian Journal of Medicine
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.91-97
- Anahtar Kelimeler: Acinetobacter baumannii, lung cancer, Pseudomonas aeruginosa, synergistic effect, vitamin
- Erzincan Binali Yıldırım Üniversitesi Adresli: Hayır
Özet
Background: Recent research has unveiled that approximately 50%-70% of patients afflicted with lung cancer also receive concurrent diagnoses of lung infections, most notably pneumonia. Among the critical multi-drug-resistant pathogens frequently isolated from pneumonia-afflicted patients, Pseudomonas aeruginosa and Acinetobacter baumannii stand prominent. Here, we assessed the impact of antibiotics and vitamins on the lung cancer infection cell culture. Methods: The study delves into the antimicrobial properties of vitamins P, K, and E against A. baumannii and P. aeruginosa, employing the minimum inhibitory concentration method and scrutinizing biofilm formation within the A549 cell culture. Results: The combined application of vitamins and antibiotics exhibited a statistically significant effect on both the minimal inhibitory concentration values and biofilm formation (P < .05). Within the realm of fat-soluble vitamins, vitamins K and E, when integrated with antibiotics, revealed varying degrees of influence, with vitamin K displaying the most substantial fractional inhibitory concentration value. Vitamin E, on the other hand, demonstrated a comparatively weaker fractional inhibitory concentration than the other constituents. Nevertheless, it exhibited robust optical density and a pronounced capacity to inhibit biofilm formation. Moreover, among the vitamin groups, it is evident that vitamin E surpasses the efficacy of others (antibac-terials affecting K < P < E). The collective application of all vitamins manifested the most potent fractional inhibitory concentration. Conclusion: The synergistic effects of vitamins with antibiotics, as evidenced in this study, may offer a promis-ing alternative for treating multidrug-resistant A. baumannii and P. aeruginosa, subject to further investigation through molecular studies.