FRUITFUL REMEDIES: ANALYZING THERAPEUTIC POTENTIALS IN ESSENTIAL AND FATTY OILS, AND AQUEOUS EXTRACTS FROM PRUNUS CERASIFERA, MALUS SYLVESTRIS, AND CORNUS MAS USING LC-MS AND GC-MS MEYVELERDEN ŞİFAYA: PRUNUS CERASIFERA, MALUS SYLVESTRIS VE CORNUS MAS TÜRLERİNDEN ELDE EDİLEN UÇUCU YAĞLAR, YAĞ ASİTLERİ VE SU EKSTRELERİNİN LC-MS VE GC-MS YÖNTEMLERİYLE TERAPÖTİK POTANSİYELLERİNİN ANALİZİ

AYDIN B., YUCA H., ÖZTÜRK G., Tekman E., KARAKAYA S., Göger G., ...More

Ankara Universitesi Eczacilik Fakultesi Dergisi, vol.49, no.2, pp.402-424, 2025 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 2
  • Publication Date: 2025
  • Doi Number: 10.33483/jfpau.1562768
  • Journal Name: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Journal Indexes: Scopus, Central & Eastern European Academic Source (CEEAS), EMBASE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.402-424
  • Keywords: Anticholinesterase, antidiabetic, Cornus mas, LC-MS/MS, Malus sylvestris, Prunus cerasifera
  • Erzincan Binali Yildirim University Affiliated: Yes

Abstract

Objective: The chemical composition and bioactive properties of essential oils, fatty oils and aqueous extracts of Prunus cerasifera, Malus sylvestris and Cornus mas were investigated. Material and Method: Antidiabetic, antimicrobial, anticholinesterase and antioxidant activities of P. cerasifera, M. sylvestris and C. mas were reported. The quantitative determination of some secondary metabolites was also analysed by LC-MS/MS. The chemical composition of the essential oils was also investigated by GC-MS. Result and Discussion: Fatty oils’ major compounds were oleic acid (77.1%) in P. cerasifera, palmitic acid (32.5%) in M. sylvestris fruits, and linoleic acid (43.2%) in C. mas seeds. Benzaldehyde (70.1%), nonacosane (30.4%), (E,E)-2,4-Decadienal (43.3%) were found as major compounds of P. cerasifera, M. sylvestris fruits, and C. mas seed essential oils, respectively. Quinic acid was predominant compound in all extracts, ranging from 11262.2996 to 18179.6260 ng/ml. C. mas fatty oil was showed antimicrobial activity against Candida albicans and C. parapsilosis with MIC =625-1250 µg/ml. P. cerasifera, C. mas, and M. sylvestris hold potential as α-glucosidase inhibitors, with varying degrees of potency. IC50 values further underscore effectiveness of aqueous extracts, especially in cases of C. mas and M. sylvestris with <10 and 399 µg/ml.