Pharmacokinetics of intravenous and intramuscular danofloxacin in red-eared slider turtles (Trachemys scripta elegans)


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Corum O., Corum D. D. , Altan F., Er A., ÇETİN G. , Uney K.

JOURNAL OF VETERINARY MEDICAL SCIENCE, vol.81, no.5, pp.753-757, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 81 Issue: 5
  • Publication Date: 2019
  • Doi Number: 10.1292/jvms.18-0609
  • Title of Journal : JOURNAL OF VETERINARY MEDICAL SCIENCE
  • Page Numbers: pp.753-757
  • Keywords: bioavailability, danofloxacin, pharmacokinetics, red-eared slider turtles, PHARMACODYNAMIC INTEGRATION, DEPLETION, TISSUE

Abstract

This study aimed to investigate the pharmacokinetics of danofloxacin in red-eared slider turtle (Trachemys scripta elegans) following a single intravenous (IV) and intramuscular (IM) administrations of 6 mg/kg, using a two-way crossover study with 30-day washout period. Eight clinically healthy red-eared slider turtle weighing 410-600 g (mean 490 g) were used for the study. Danofloxacin concentrations were measured using the reversed-phase high-performance liquid chromatography. The plasma concentration-time data were evaluated by a non-compartmental method. After IV administration, the elimination half-life (t(1/2 lambda z)), mean residence time (MRT0-8), area under the concentration-time curve (AUC(0-infinity)), volume of distribution at steady state and total body clearance in plasma were 24.17 hr, 30.64 hr, 143.31 hr center dot mu g/ml, 1.29 l/kg and 0.04 l/hr/kg, respectively. Following IM administration, t1/2.z, MRT0-infinity, AUC(0-infinity), peak concentration (C-max), time to reach Cmax, and bioavailability in plasma were 32.00 hr, 41.15 hr, 198.23 hr center dot mu g/ml, 8.75 mu g/ml, 1.5 hr and 139.89%, respectively. Danofloxacin has clinically superior pharmacokinetic properties, including the complete IM absorption, slow elimination and wide volume of distribution in redeared slider turtles. However, further pharmacokinetics/pharmacodynamics studies are necessary for the treatment of diseases caused by susceptible bacteria with known minimum inhibitory concentration values in red-eared slider turtles.