Chondroprotective effects of a new glucosamine combination in rats: Gene expression, biochemical and histopathological evaluation

UCUNCU, Yilmaz; CELIK, Nuray; OZTURK, Cengiz; TURKOGLU, Murat; Cetin, NİHAL; KOÇKARA, NİZAMETTİN; SENER, Ebru; DUNDAR, Cihat; ARSLAN, Aynur; DOĞAN, Hasan; Kurt, NEZAHAT; SÜLEYMAN, HALİS

doi:10.1016/j.lfs.2015.03.012

Chondroprotective effects of a new glucosamine combination in rats: Gene expression, biochemical and histopathological evaluation

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UCUNCU Y., CELIK N., OZTURK C., TURKOGLU M., Cetin N., KOÇKARA N., ...More

Life Sciences, vol.130, pp.31-37, 2015 (SCI-Expanded)

Publication Type: Article / Article
Volume: 130
Publication Date: 2015
Doi Number: 10.1016/j.lfs.2015.03.012
Journal Name: Life Sciences
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.31-37
Keywords: Glucosamine, IL-1 beta, TNF-alpha, Rat, OXIDATIVE DNA-DAMAGE, HARPAGOPHYTUM-PROCUMBENS, NITRIC-OXIDE, IN-VITRO, ELECTROCHEMICAL DETECTION, CHONDROITIN SULFATE, INDUCED ARTHRITIS, RABBIT MODEL, BROMELAIN, OSTEOARTHRITIS
Erzincan Binali Yildirim University Affiliated: Yes

Abstract

Aims: This study investigates the effect of a new combination of glucosamine hydrochloride, chondroitin sulfate, methylsulfonylmethane, Harpagophytum procumbens root extract (standardized to 3% harpagoside) and bromelain extract (GCMHB) on formalin-induced damage to cartilage tissue in the rat knee joint and evaluates this combination in comparison with another combination of glucosamine hydrochloride, chondroitin sulfate and methylsulfonylmethane (GKM).