Chondroprotective effects of a new glucosamine combination in rats: Gene expression, biochemical and histopathological evaluation


UCUNCU Y., CELIK N., OZTURK C., TURKOGLU M., Cetin N., KOÇKARA N., ...More

Life Sciences, vol.130, pp.31-37, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 130
  • Publication Date: 2015
  • Doi Number: 10.1016/j.lfs.2015.03.012
  • Journal Name: Life Sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.31-37
  • Keywords: Glucosamine, IL-1 beta, TNF-alpha, Rat, OXIDATIVE DNA-DAMAGE, HARPAGOPHYTUM-PROCUMBENS, NITRIC-OXIDE, IN-VITRO, ELECTROCHEMICAL DETECTION, CHONDROITIN SULFATE, INDUCED ARTHRITIS, RABBIT MODEL, BROMELAIN, OSTEOARTHRITIS
  • Erzincan Binali Yildirim University Affiliated: Yes

Abstract

Aims: This study investigates the effect of a new combination of glucosamine hydrochloride, chondroitin sulfate, methylsulfonylmethane, Harpagophytum procumbens root extract (standardized to 3% harpagoside) and bromelain extract (GCMHB) on formalin-induced damage to cartilage tissue in the rat knee joint and evaluates this combination in comparison with another combination of glucosamine hydrochloride, chondroitin sulfate and methylsulfonylmethane (GKM).