A novel approach to contrast-induced nephrotoxicity: the melatonergic agent agomelatine.

KARAMAN, Adem; Diyarbakir, Busra; Durur-Subasi, Irmak; KÖSE, Duygu; Ozbek-Bilgin, ASLI; Topcu, Atilla; Gundogdu, Cemal; Durur-Karakaya, Afak; Bayraktutan, Zafer; ALPER, Fatih

doi:10.1259/bjr.20150716

A novel approach to contrast-induced nephrotoxicity: the melatonergic agent agomelatine.

KARAMAN A., Diyarbakir B., Durur-Subasi I., KÖSE D., Ozbek-Bilgin A., Topcu A., ...Daha Fazla

The British journal of radiology, cilt.89, sa.1061, ss.20150716, 2016 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 89 Sayı: 1061
Basım Tarihi: 2016
Doi Numarası: 10.1259/bjr.20150716
Dergi Adı: The British journal of radiology
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.20150716
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Erzincan Binali Yıldırım Üniversitesi Adresli: Hayır

Özet

Objective: To study the potential nephroprotective role of agomelatine in rat renal tissue in cases of contrast-induced nephrotoxicity (CIN). The drug's action on the antioxidant system and proinflammatory cytokines, superoxide dismutase (SOD) activity, levels of glutathione (GSH) and malondialdehyde (MDA) and the gene expression of interleukin-6 (IL-6), tumour necrosis factor (TNF)-alpha and nuclear factor kappa B (NF-kappa B) was measured. Tubular necrosis and hyaline and haemorrhagic casts were also histopathologically evaluated.