Isolation, characterization and antiproliferative activity of secondary metabolites from tanacetum alyssifolium (Bornm.) grierson
Records of Natural Products, vol.15, no.2, pp.122-129, 2021 (SCI-Expanded, Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 15 Issue: 2
- Publication Date: 2021
- Doi Number: 10.25135/rnp.201.20.07.1702
- Journal Name: Records of Natural Products
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, ABI/INFORM, CAB Abstracts, EMBASE, Veterinary Science Database, TR DİZİN (ULAKBİM)
- Page Numbers: pp.122-129
- Keywords: Tanacetum alyssifolium, sesquiterpene lactones, cytotoxicity, MCF-7 cell line
- Open Archive Collection: AVESIS Open Access Collection
- Erzincan Binali Yildirim University Affiliated: Yes
Abstract
© 2020 ACG Publications.Secondary metabolites of Tanacetum alyssifolium (Bornm.) Grierson (Asteraceae) were investigated for the first time. Thirteen compounds including axillarin (1), Luteolin-7-O-β-glucoside (8) and rutin (13) as flavonoids, fraxetin (7), isofraxidin (9), isofraxidin-7-O-glucoside (11) and fraxidin (12) as coumarins, tatridin A (2), altissin (3), tamirin (4) and tanachin (5) as sesquiterpene lactones and 2,4-dihydroxy-6-methoxy acetophenone (6) and picein (10) as acetophenone derivatives were isolated from the methanol extract of the species. The structures of all isolated compounds were elucidated by 1D and 2D-NMR techniques and by comparing with the literature data. In addition, in vitro cytotoxic activity of all isolated compounds was evaluated against breast cancer MCF-7 cell line by XTT assay. Sesquiterpene lactones; tatridin A (2), tamirin (4) and tanachin (5) were found to be the most cytotoxic molecules against MCF-7 cell line.