Ferruginoside D: A Novel Phenylethanoid from Verbascum leiocarpum
Chemistry and Biodiversity, vol.20, no.12, 2023 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 20 Issue: 12
- Publication Date: 2023
- Doi Number: 10.1002/cbdv.202301200
- Journal Name: Chemistry and Biodiversity
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
- Keywords: antioxidant activity, antiproliferative activity, secondary metabolite, Verbascum leiocarpum, α-glucosidase inhibitory
- Open Archive Collection: AVESIS Open Access Collection
- Erzincan Binali Yildirim University Affiliated: Yes
Abstract
A novel phenylethanoid, ferruginoside D, together with fourteen known compounds were isolated from the Verbascum leiocarpum for the first time. Chemical structures of isolated compounds were determined by spectroscopic analysis including HR-ESI-MS and NMR spectra. The antioxidant, α-glucosidase inhibitory properties, and antiproliferative activities against multiple cell lines (A172, C6, HeLa, A2780, SW620, HT29, Beas2B, RPE, and HSF) of the isolated compounds were evaluated in vitro. According to the results, iridoids, flavonoids (luteolin and apigenin), and phenylethanoids (poliumoside and isoverbascoside) with strong antiproliferative potential were also found to have cytostatic effects. Furthermore, the investigation revealed that compounds luteolin, poliumoside, verbascoside, isoverbascoside, ferruginoside C, ferruginoside D, and ursolic acid show potent alpha-glucosidase inhibitory activity, while compounds luteolin, verbascoside, and isoverbascoside exhibit substantial antioxidant activity. The new compound (ferruginoside D) was found moderately active against cancer cell lines, with strong alpha-glucosidase inhibitory activity, and moderate antioxidant properties.