This study aims to examine the relationship among travel constraints, travel motivations, and destination choice via a multi-method approach. For this purpose, two studies and two analysis tools-PLS-SEM and fsQCA-were employed to conduct examinations in the context of two different target destinations (France and China). Findings revealed that travel constraints and travel motivations generally influenced destination choice. However, it was found that PLS-SEM and fsQCA results were not compatible for some relationships. In light of this and further findings, it was observed that the matter of destination choice is complex by nature.