Pharmacokinetics of meloxicam, carprofen, and tolfenamic acid after intramuscular and oral administration in Japanese quails (Coturnix coturnix japonica)


Turk E., Tekeli I. O. , Corum O., Corum D. D. , Kirgiz F. C. , ÇETİN G. , ...More

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, vol.44, no.3, pp.388-396, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.1111/jvp.12972
  • Title of Journal : JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
  • Page Numbers: pp.388-396
  • Keywords: carprofen, meloxicam, pharmacokinetics, quails, tolfenamic acid

Abstract

The aim of this study was to determine the pharmacokinetics of meloxicam (MLX), carprofen (CRP), and tolfenamic acid (TA) in Japanese quails (Coturnix coturnix japonica) following intramuscular (IM) and oral administration at doses of 1, 10, and 2 mg/kg, respectively. A total of 72 quails were randomly divided into 3 equal groups as MLX, CRP, and TA. Each group was separated into two sub-groups that received IM and oral administration of each drug. Plasma concentrations of MLX, CRP, and TA were determined using HPLC-UV and analyzed by non-compartmental method. The t(1/2z) and MRT of MLX, CRP, and TA after oral administration were similar to those after IM administration. The V-darea/F of MLX, CRP, and TA after IM administration was 0.28, 2.05, and 0.20 L/kg. The Cl/F of MLX, CRP, and TA after IM administration was 0.12, 0.19, and 0.09 L/h/kg. MLX, CRP, and TA after oral administration showed significantly lower C-max and longer T-max compared with IM administration. The relative bioavailability of MLX, CRP, and TA following oral administration in quails was 76.13%, 61.46%, and 57.32%, respectively. The IM and oral route of MLX, CRP, and TA can be used for the treatment of various conditions in quails. However, further research is necessary to determine the pharmacodynamics and safety of MLX, CRP, and TA before use in quails.