A new HLA susceptibility haplotype defined in three familial cases of frontal fibrosing alopecia Üç ailevi frontal fibrozan alopesi vakasında tanımlanan yeni bir HLA duyarlılık haplotipi

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Özdemir A. K., Hayran Y., ÖZMEN F., Korkut M. G., Çakmak S. K.

Turkderm Turkish Archives of Dermatology and Venereology, cilt.59, sa.2, ss.66-69, 2025 (ESCI, Scopus, TRDizin) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 2
  • Basım Tarihi: 2025
  • Doi Numarası: 10.4274/turkderm.galenos.2025.63373
  • Dergi Adı: Turkderm Turkish Archives of Dermatology and Venereology
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.66-69
  • Anahtar Kelimeler: Familial frontal fibrosing alopecia, genetic susceptibility, HLA haplotypes, scarring alopecia
  • Erzincan Binali Yıldırım Üniversitesi Adresli: Evet

Özet

Frontal fibrosing alopecia (FFA) is a scarring alopecia that primarily affects postmenopausal women. Although its etiology remains unknown, familial cases suggest a genetic basis. In this case report, we present the findings of three sisters with familial FFA, aged 55, 60, and 62 years, from Türkiye. Genetic analysis revealed that all three sisters shared the human leukocyte antigen (HLA)-A*11:01; B*35:01; C*04:01 haplotypes. Two sisters had HLA-DRB1*03:01 and HLA-DQB1*02:01, while the third had HLA-DRB1*01:01; HLA-DQB1*05:01. The shared HLA-A*11:01, B*35:01, and C*04:01 haplotype has not been previously associated with familial FFA. This finding marks the first familial FFA report from Türkiye and suggests a new genetic susceptibility haplotype for FFA in the Turkish population. The variation in HLA-DRB1 and HLADQB1 alleles among the sisters indicates complex genetic influences on the familial FFA. Further research is required to determine the role of these genetic variations in disease progression and to identify potential therapeutic approaches.