Pharmacokinetics of cefquinome in red-eared slider turtles (Trachemys scripta elegans) after single intravenous and intramuscular injections


Uney K., Altan F., ÇETİN G. , Aboubakr M., Dik B., Sayin Z., ...More

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, vol.41, no.1, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume: 41 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1111/jvp.12448
  • Title of Journal : JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
  • Keywords: cefquinome, pharmacokinetics, red-eared slider turtle, BROAD-SPECTRUM CEPHALOSPORIN, CARETTA-CARETTA, BIOAVAILABILITY, INFECTIONS, EXPOSURE, PLASMA

Abstract

The purpose of this study was to evaluate the pharmacokinetics of cefquinome (CFQ) following single intravenous (IV) or intramuscular (IM) injections of 2mg/kg body weight in red-eared slider turtles. Plasma concentrations of CFQ were determined by high-performance liquid chromatography and analyzed using noncompartmental methods. The pharmacokinetic parameters following IV injection were as follows: elimination half-life (t(1/2z)) 21.73 +/- 4.95hr, volume of distribution at steady-state (V-dss) 0.37 +/- 0.11L/kg, area under the plasma concentration-time curve (AUC(0-)) 163 +/- 32ghr(-1)ml(-1), and total body clearance (Cl-T) 12.66 +/- 2.51 mlhr(-1)kg(-1). The pharmacokinetic parameters after IM injection were as follows: peak plasma concentration (C-max) 3.94 +/- 0.84g/ml, time to peak concentration (T-max) 3hr, t(1/2z) 26.90 +/- 4.33hr, and AUC(0-) 145 +/- 48ghr(-1)ml(-1). The bioavailability after IM injection was 88%. Data suggest that CFQ has a favorable pharmacokinetic profile with a long half-life and a high bioavailability in red-eared slider turtles. Further studies are needed to establish a multiple dosage regimen and evaluate clinical efficacy.